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Kazuhiko ISHIHARA Professor
Kazuhiko ISHIHARA Professor
Field of Study: Biomaterials and Biointerfaces
  • [MAIL] ishihara@mpc.t.u-tokyo.ac.jp
  • [URL] http://www.mpc.t.u-tokyo.ac.jp

Bioinspired Polymers and Their Biomedical Functions

In this laboratory, we are developing novel polymer biomaterials based on molecular design with strong inspiration from the surface structure of biomembrane. That is, the polymers with phospholipid polar group in the side chain, 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers were synthesized. The MPC polymers can inhibit surface-induced clot formation effectively, even when they contact with blood in the absence of anticoagulant. This phenomenon was due to reduction of plasma protein and suppression of denaturation of adsorbed proteins. As the molecular structure of the MPC polymer was easily designed by changing monomer units and composition, it could apply to surface modification of artificial organs and biomedical devices. Moreover, we also apply the polymer biomaterials for every bioengineering field.

Subjects of Reseach

  • Synthesis of phospholipid polymers and application for biomaterials
  • Characterization of interaction between cell and polymer materials
  • Study on polymeric membranes with permeability for proteins
  • Design of photo-living radical polymerization system and development of functional polymer materials
  • Design of stimuli-responsive polymer materials by biomolecules
  • Study on bio-inspired polymer gel
  • Stabilization of bioactive substances in aqueous solution with phospholipid polymer